A Phase I Dose Escalation Study of Intratumoral VCN-01 Injections With Gemcitabine and Abraxane® in Patients With Advanced Pancreatic Cancer
Brief Description
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Phase I clinical trial with aims in determining the recommended dose for phase II trials as well as the
safety of intratumoral injections of VCN-01 with with Abraxane®/gemcitabine. Pancreatic Adenocarcinoma Metastatic Pancreatic Adenocarcinoma Phase I January 2014 - April 2016 Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain Centro Integral Oncológico Clara Campal, Madrid, Spain, Hospital Universitario 12 de Octubre, Madrid, Spain |
Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Brief Description
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Phase Ib clinical trial with aims in determinng optimal dosage of wild-type reovirus in combination with bortezomib and dexamethasone.
Recurrent Plasma Cell Myeloma Refractory Plasma Cell Myeloma Phase I August 2015-August 2017 USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States |
HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors
Brief Description
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Phase I clinical trials with aims in determining the safety of HSV1716 injection in extracranial solid tumors of adolescents and young adults.
Rhabdomyosarcoma Osteosarcoma Ewing Sarcoma Soft Tissue Sarcoma Neuroblastoma Wilms Tumor Malignant Peripheral Nerve Sheath Tumor Clival Chordoma Non-CNS Solid Tumors Phase 1 March 2010- December 2016 Nationwide Children's Hospital, Columbus, Ohio, United States |
Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery
Brief Description
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Phase I clinical trial with aims to determine dosage and safety of intrapleural measles virus therapy.
Recurrent Childhood Anaplastic Astrocytoma Recurrent Childhood Anaplastic Oligoastrocytoma Recurrent Childhood Anaplastic Oligodendroglioma Recurrent Childhood Giant Cell Glioblastoma Recurrent Childhood Glioblastoma Recurrent Childhood Gliomatosis Cerebri Recurrent Childhood Gliosarcoma Phase 1 December 2013- February 2017 Cincinnati Children's Hospital Medical Center,Cincinnati, Ohio, United States |
Phase I / II Study Of ColoAd1 Intraperitoneally in Ovarian Cancer Patients (OCTAVE)
Brief Description
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Phase I/II clinical trials for ColoAd1 to determine the optimal dosage and the efficacy of ColoAd1 as a monotherapy for platinum-resistant ovarian cancer.
Patients With Recurrent, Platinum-resistant Ovarian Cancer. Phase I/II January 2014- June 2016 The Royal Surrey County Hospital, Guildford, Surrey, United Kingdom Beatson Institute, Glasgow, United Kingdom St James's University HospitalRecruiting, Leeds, United Kingdom The Christie Hospital, Manchester, United Kingdom |
Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma
Brief Description
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Phase I clinical trial with aims to determine the side effects of HSV1716 injection at tumor resection cavity during surgery.
Recurrent Malignant Mesothelioma, Stage IA Malignant Mesothelioma, Stage IB Malignant Mesothelioma, Stage II Malignant Mesothelioma, Stage III Malignant Mesothelioma, Stage IV Malignant MesotheliomaStage IA Malignant Mesothelioma, Stage IB Malignant Mesothelioma, Stage II Malignant Mesothelioma, Stage III Malignant Mesothelioma, Stage IV Malignant Mesothelioma Phase 1 November 2011 Mayo Clinic, Rochester, Minnesota, United States |
UARK 2014-21 A Phase II Trial of Oncolytic Virotherapy by Systemic Administration of Edmonston Strain of Measles Virus
Brief Description
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Phase 2 clinical trial with aims to determine the clinical efficacy of MV-NIS (measles virus-sodium iodide symporter) therapy for people with relapsed/refractory myeloma when given with cyclophosphamide.
Multiple Myeloma Phase 2 March 2015- August 2016 University of Arkansas for Medical Science, Little Rock, Arkansas, United States, |